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DEPARTAMENT de BIOQUIMICA i BIOLOGIA MOLECULAR



























Recerca > Grups d'Investigació

GABRMN (Grup d'Aplicacions Biomèdiques de la Ressonància Magnètica Nuclear)




Dades bàsiques




Àrees Investigació
BIOQUÍMICA I BIOLOGIA MOLECULAR DEL SISTEMA NERVIÓS; METABOLISME IN VIVO

Investigador/s
Carles Arús
Tel: 1257
enviar e-mail

Descripció
GABRMN stands for "Grup d'Aplicacions Biomèdiques de la Ressonància Magnètica Nuclear”. Our research group works in the Biomedical Applications of Magnetic Resonance. We belong to the Biochemistry and Molecular Biology Department located at the Faculty of Biosciences (Preclinical models team), and at the Institut de Biotecnologia i Biomedicina (DSS development team) of the Universitat Autònoma de Barcelona. Professor Carles Arús is our group leader: Our present research interests are: • Biomedical applications of Nuclear Magnetic Resonance Spectroscopy (NMR) • Development of Decision Support Systems (DSS) based on Magnetic Resonance Spectroscopy (MRS) for clinical diagnosis of human brain tumours • In vivo tumour progression/therapy response markers in preclinical models of cancer using molecular imaging-based in vivo MRS.

Personal
Magdalena Ciezka (Becaria pre-doctoral); Elena Jiménez (Becaria pre-doctoral); Milena Acosta González (Becaria pre-doctoral); Myriam Dávila Huerta (Becaria pre-doctoral); Silvia Ferrer (Becaria pre-doctoral); Sandra Ortega (Becaria pre-doctoral); Juana Martin (Becaria pre-doctoral); Ana Paula Candiota Silveira (Investigadora post-doctoral); Margarida Julià Sapé (Investigadora post-doctoral); Teresa Delgado (Becaria pre-doctoral); Alina Garcia (Administradora sistemes i programadora informàtica)




Publicacions




D. Valverde-Saubí, AP. Candiota, MA. Molins, M. Feliz, O. Godino, M. Dávila, JJ. Acebes, C. Arús (2010)
Short-term temperature effect on the HRMAS spectra of human brain tumor biopsies and their pattern recognition analysis.
MAGMA, Vol: 23, 203-15

RV. Simões, T. Delgado-Goñi, S. Lope-Piedrafita, C. Arús (2010)
1H-MRSI pattern perturbation in a mouse glioma: the effects of acute hyperglycemia and moderate hypothermia.
NMR Biomed, Vol: 23, 23-33

X. Castells, JJ. Acebes, S. Boluda, A. Moreno-Torres, J. Pujol, M. Julià-Sapé, AP. Candiota, J. Ariño, A. Barceló, C. Arús (2010)
Development of a predictor for human brain tumors based on gene expression values obtained from two types of microarray technologies.
OMICS, Vol: 14, 157-64

A. Pérez-Ruiz, M. Julià-Sapé, G. Mercadal, I. Olier, C. Majós, C. Arús (2010)
The INTERPRET Decision-Support System version 3.0 for evaluation of Magnetic Resonance Spectroscopy data from human brain tumours and other abnormal brain masses.
BMC Bioinformatics, Vol: 11, 581

Majós C, Bruna J, Julià-Sapé M, Cos M, Camins A, Gil M, Acebes JJ, Aguilera C, Arús C. (2010)
Proton MR Spectroscopy Provides Relevant Prognostic Information in High-Grade Astrocytomas.
AJNR Am J Neuroradiol,

S. Ortega-Martorell, I. Olier, M. Julià-Sapé, C. Arús (2010)
SpectraClassifier 1.0: a user friendly, automated MRS-based classifier-development system.
BMC Bioinformatics, Vol: 11, 106

M. Quintero, ME. Cabañas, C. Arús (2010)
13C-labelling studies indicate compartmentalized synthesis of triacylglycerols in C6 rat glioma cells.
Biochim. Biophys. Acta, Vol: 1801, 693-701

C. Majós, C. Aguilera, J. Alonso, M. Julià-Sapé, S. Castañer, JJ. Sánchez, A. Samitier, A. León, A. Rovira, C. Arús (2009)
Proton MR spectroscopy improves discrimination between tumor and pseudotumoral lesion in solid brain masses.
AJNR Am J Neuroradiol, Vol: 30, 544-51

JM. García-Gómez, J. Luts, M. Julià-Sapé, P. Krooshof, S. Tortajada, JV. Robledo, W. Melssen, E. Fuster-García, I. Olier, G. Postma, D. Monleón, A. Moreno-Torres, J. Pujol, AP. Candiota, MC. Martínez-Bisbal, J. Suykens, L. Buydens, B. Celda, S. Van Huffel, C. Arús, M. Robles (2009)
Multiproject-multicenter evaluation of automatic brain tumor classification by magnetic resonance spectroscopy.
MAGMA, Vol: 22, 5-18

X. Castells, JM. García-Gómez, A. Navarro, JJ. Acebes, O. Godino, S. Boluda, A. Barceló, M. Robles, J. Ariño, C. Arús (2009)
Automated brain tumor biopsy prediction using single-labeling cDNA microarrays-based gene expression profiling.
Diagn. Mol. Pathol., Vol: 18, 206-18

C. Majós, C. Aguilera, M. Cos, A. Camins, AP. Candiota, T. Delgado-Goñi, A. Samitier, S. Castañer, JJ. Sánchez, D. Mato, JJ. Acebes, C. Arús (2009)
In vivo proton magnetic resonance spectroscopy of intraventricular tumours of the brain.
Eur Radiol, Vol: 19, 2049-59

M. van der Graaf, M. Julià-Sapé, FA. Howe, A. Ziegler, C. Majós, A. Moreno-Torres, M. Rijpkema, D. Acosta, KS. Opstad, YM. van der Meulen, C. Arús, A. Heerschap (2008)
MRS quality assessment in a multicentre study on MRS-based classification of brain tumours.
NMR Biomed, Vol: 21, 148-58

AJ. Wright, C. Arús, JP. Wijnen, A. Moreno-Torres, JR. Griffiths, B. Celda, FA. Howe (2008)
Automated quality control protocol for MR spectra of brain tumors.
Magn Reson Med, Vol: 59, 1274-81

RV. Simões, A. Martinez-Aranda, B. Martín, S. Cerdán, A. Sierra, C. Arús (2008)
Preliminary characterization of an experimental breast cancer cells brain metastasis mouse model by MRI/MRS.
MAGMA, Vol: 21, 237-49

JM. García-Gómez, S. Tortajada, C. Vidal, M. Julià-Sapé, J. Luts, A. Moreno-Torres, S. Van Huffel, C. Arús, M. Robles (2008)
The effect of combining two echo times in automatic brain tumor classification by MRS.
NMR Biomed, Vol: 21, 1112-25

RV. Simões, ML. García-Martín, S. Cerdán, C. Arús (2008)
Perturbation of mouse glioma MRS pattern by induced acute hyperglycemia.
NMR Biomed, Vol: 21, 251-64

A. Oriol, D. Valverde, J. Capellades, ME. Cabañas, JM. Ribera, C. Arús (2007)
In vivo quantification of response to treatment in patients with multiple myeloma by 1H magnetic resonance spectroscopy of bone marrow.
MAGMA, Vol: 20, 93-101

E. Rodríguez, RV. Simoes, A. Roig, E. Molins, N. Nedelko, A. Slawska-Waniewska, S. Aime, C. Arús, ME. Cabañas, C. Sanfeliu, S. Cerdán, ML. García-Martín (2007)
An iron-based T1 contrast agent made of iron-phosphate complexes: in vitro and in vivo studies.
MAGMA, Vol: 20, 27-37

JB. Poullet, MC. Martinez-Bisbal, D. Valverde, D. Monleon, B. Celda, C. Arús, S. Van Huffel (2007)
Quantification and classification of high-resolution magic angle spinning data for brain tumor diagnosis.
Conf Proc IEEE Eng Med Biol Soc, Vol: 2007, 5407-10

C. Lu, A. Devos, JA. Suykens, C. Arús, S. Van Huffel (2007)
Bagging linear sparse Bayesian learning models for variable selection in cancer diagnosis.
IEEE Trans Inf Technol Biomed, Vol: 11, 338-47

M. Julià-Sapé, D. Acosta, C. Majós, A. Moreno-Torres, P. Wesseling, JJ. Acebes, JR. Griffiths, C. Arús (2006)
Comparison between neuroimaging classifications and histopathological diagnoses using an international multicenter brain tumor magnetic resonance imaging database.
J. Neurosurg., Vol: 105, 6-14

M. Julià-Sapé, D. Acosta, M. Mier, C. Arùs, D. Watson, (2006)
A multi-centre, web-accessible and quality control-checked database of in vivo MR spectra of brain tumour patients.
MAGMA, Vol: 19, 22-33

D. Valverde, MR. Quintero, AP. Candiota, L. Badiella, ME. Cabañas, C. Arús (2006)
Analysis of the changes in the 1H NMR spectral pattern of perchloric acid extracts of C6 cells with growth.
NMR Biomed, Vol: 19, 223-30

E. Rodríguez, A. Roig, E. Molins, C. Arús, MR. Quintero, ME. Cabañas, S. Cerdán, P. Lopez-Larrubia, C. Sanfeliu (2005)
In vitro characterization of an Fe(8) cluster as potential MRI contrast agent.
NMR Biomed, Vol: 18, 300-7

AP. Candiota, C. Majós, A. Bassols, ME. Cabañas, JJ. Acebes, MR. Quintero, C. Arús (2004)
Assignment of the 2.03 ppm resonance in in vivo 1H MRS of human brain tumour cystic fluid: contribution of macromolecules.
MAGMA, Vol: 17, 36-46

A. Moreno-Torres, I. Martínez-Pérez, M. Baquero, J. Campistol, A. Capdevila, C. Arús, J. Pujol (2004)
Taurine detection by proton magnetic resonance spectroscopy in medulloblastoma: contribution to noninvasive differential diagnosis with cerebellar astrocytoma.
Neurosurgery, Vol: 55, 824-9; discussion 829

A. Devos, L. Lukas, JA. Suykens, L. Vanhamme, AR. Tate, FA. Howe, C. Majós, A. Moreno-Torres, M. van der Graaf, C. Arús, S. Van Huffel (2004)
Classification of brain tumours using short echo time 1H MR spectra.
J. Magn. Reson., Vol: 170, 164-75

L. Lukas, A. Devos, JA. Suykens, L. Vanhamme, FA. Howe, C. Majós, A. Moreno-Torres, M. Van der Graaf, AR. Tate, C. Arús, S. Van Huffel (2004)
Brain tumor classification based on long echo proton MRS signals.
Artif Intell Med, Vol: 31, 73-89

C. Majós, J. Alonso, C. Aguilera, M. Serrallonga, S. Coll, JJ. Acebes, C. Arús, J. Gili (2003)
Utility of proton MR spectroscopy in the diagnosis of radiologically atypical intracranial meningiomas.
Neuroradiology, Vol: 45, 129-36

AR. Tate, C. Majós, A. Moreno, FA. Howe, JR. Griffiths, C. Arús (2003)
Automated classification of short echo time in in vivo 1H brain tumor spectra: a multicenter study.
Magn Reson Med, Vol: 49, 29-36

C. Majós, J. Alonso, C. Aguilera, M. Serrallonga, J. Pérez-Martín, JJ. Acebes, C. Arús, J. Gili (2003)
Proton magnetic resonance spectroscopy ((1)H MRS) of human brain tumours: assessment of differences between tumour types and its applicability in brain tumour categorization.
Eur Radiol, Vol: 13, 582-91

C. Majós, J. Alonso, C. Aguilera, M. Serrallonga, JJ. Acebes, C. Arús, J. Gili (2002)
Adult primitive neuroectodermal tumor: proton MR spectroscopic findings with possible application for differential diagnosis.
Radiology, Vol: 225, 556-66

Y. Pérez, H. Lahrech, ME. Cabañas, R. Barnadas, M. Sabés, C. Rémy, C. Arús (2002)
Measurement by nuclear magnetic resonance diffusion of the dimensions of the mobile lipid compartment in C6 cells.
Cancer Res., Vol: 62, 5672-7

I. Barba, P. Mann, ME. Cabañas, C. Arús, C. Gasparovic (2001)
Mobile lipid production after confluence and pH stress in perfused C6 cells.
NMR Biomed, Vol: 14, 33-40

J. Underwood, AR. Tate, R. Luckin, C. Majós, A. Capdevila, F. Howe, J. Griffiths, C. Arús (2001)
A prototype decision support system for MR spectroscopy-assisted diagnosis of brain tumours.
Stud Health Technol Inform, Vol: 84, 561-5

I. Barba, A. Moreno, I. Martinez-Pérez, AR. Tate, ME. Cabañas, M. Baquero, A. Capdevila, C. Arús (2001)
Magnetic resonance spectroscopy of brain hemangiopericytomas: high myoinositol concentrations and discrimination from meningiomas.
J. Neurosurg., Vol: 94, 55-60

I. Barba, ME. Cabañas, C. Arús (1999)
The relationship between nuclear magnetic resonance-visible lipids, lipid droplets, and cell proliferation in cultured C6 cells.
Cancer Res., Vol: 59, 1861-8



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